The 12-day imposed war waged by the United States and the Israeli regime against the Islamic Republic of Iran in June 2025 represents a significant example of the transformation of hybrid warfare in the age of artificial intelligence. This study aims to analyze the role of artificial intelligence in the defense and security dimensions of this conflict and to elucidate its effects on the intelligence, decision-making, and action cycle. In terms of purpose, the study is applied and policy-oriented; in terms of approach, it is qualitative; and in terms of analytical method, it employs framework analysis. Data were collected through documentary research and field observation and were examined, validated, and supplemented with input from 12 defense and security experts. The analytical framework is based on four dimensions: intelligence, operations, defense, and cyber operations. The findings indicate that, in this war, artificial intelligence functioned not as an isolated tool but as an integrated architecture encompassing data, algorithms, command and control, and operational platforms. Through the compression of the intelligence cycle, rapid targeting—with an 87% success rate in identifying high-value targets—shortening the kill chain to as little as 60 seconds, the intelligent enhancement of air and missile defense, and the reinforcement of cyber operations, artificial intelligence increased the speed and precision of the combat cycle. The study concludes that strategic advantage in future warfare will depend less on possessing any single technology than on the capacity to integrate data, decision-making, and action.